LISTE DES PROJET SCIENTIFIQUES EN COURS (2025)
PROJECT 1. Bacterial ecology and antibiotic resistance profile of bacteria in three CHUS in the city of N’Djaména (CHU le Bons Samaritain, CHU Mère- Enfant and CHU de la Référence Nationale)/CHAD. PhD Student: Djallaye DJIMTOIBAYE. Financial support: CHU-BS.
Description : Bacterial infections in hospitals are frequent, despite the various measures that have been implemented, and the mechanism persists due to invasive procedures. The number of multi-resistant bacteria (MRB) is constantly increasing, with bacteria now possessing the ability to acquire resistance mechanisms that can stand up to the pharmaceutical industry’s production of broad-spectrum antibiotics.
Bacterial resistance is a global and growing phenomenon, with bacteria that are increasingly resistant, or even resistant to all antibiotics, combined with a dwindling therapeutic arsenal,
making this issue a real threat to public health.
PROJECT 2 : Global situation of CoVID-19 in Chad: 2020 to 2023. PhD student: Koutaya DEZOUMBE.
Financial support: MAGIS (Italian Cooperation)
Description : Since the onset of the COVID-19 pandemic, Chad has faced unique challenges in understanding the spread and evolution of SARS-CoV-2. The capital, N’Djamena, emerged as a hotspot, necessitating comprehensive epidemiological and genomic investigations. This research synthesizes findings from two key studies: one on the genomic profile of SARS-CoV-2 variants in N’Djamena and another on seroprevalence rates across various provinces in Chad.
PROJECT 3 : Screening, characterization and prevention of hepatitis b in newborns and students at N’djamena chu-bs. PhD Student: ROUTOUBE Monique. Financial support: MAGIS (Italian Cooperation)
Description : Hepatitis B is a viral infection that attacks the liver and can cause both acute and chronic illness. The virus is most often transmitted from mother to child during childbirth, in infancy, and through contact with blood or other body fluids during sex with an infected partner, unsafe injections or exposure to sharp instruments. WHO estimates that 254 million people will be living with chronic hepatitis B infection in 2022, with 1.2 million new infections every year. In 2022, hepatitis B caused around 1.1 million deaths, mainly due to cirrhosis and hepatocellular carcinoma (primary liver cancer), including 124,000 deaths in the African Region.
PROJECT 4 : Study of the acquisition of bacterial resistance to antibiotics and medicinal plant extracts: the case of nosocomial infections. PhD student: Akouya AMINE. Financial support: CNR
(Italian Cooperation)
Description : Antimicrobial resistance (AMR), one of the major public health threats of the 21st century, is a global public health challenge together with the development and diffusion of new
viral variants that seriously affects efforts to combat epidemics, particularly in resource-limited countries such as Chad [2]. The issue of antibiotic resistance is currently of major concern to the scientific community, as it has become vital to find new antimicrobial agents for therapeutic than preventive purposes. To this end, researchers have turned their attention to the plant world, particularly medicinal and nutritional plants, which offer inestimable potential for the discovery of phytomedicines with antibacterial properties. The aim of this project is to valorise the Chadian vegetal and cultural biodiversity to discover, exploit and generate new based plant products for prevention and management of microbial diffusion with particular regards to the hospital-acquired infections.
PROJECT 5 : Evaluation of the efficacy of artemether lumefantrine, monitoring of molecular markers of plasmodium resistance to artemisinin and Pharmacogenetics of antimalarial drugs in Chad. PhD Student: NOUBARAMDJI YAMTI SUITOMBAYE. Financial support: MAGIS (Italian Cooperation)
PROJECT 6 : Genotypic Distribution and Risk Factors Associated With Cervicovaginal Human Papillomavirus (Hpv) Infection In Chad. PhD Student: Routoube Monique. Financial support: MAGIS (Italian Cooperation)
Description : Cervical cancer is a disease caused by a sexually transmitted virus, the human papillomavirus (HPV). It is a major public health problem worldwide. In 2020, it is estimated to be the fourth most common cancer in women, with 604,127 new cases and 342,000 deaths.
Cervical cancer is mainly caused by persistent HPV infection, an agent also responsible for benign tumours and malignant tumours in various parts of the body (genital, anal, oral). A distinction is made between so-called low-risk non-oncogenic HPV (BR-HPV) and so-called high-risk oncogenic HPV (HR-HPV). Oncogenic HR-HPVs are responsible for 7.7% of cancers in developing countries, mainly cervical cancer. Although all HR-HPV genotypes have oncogenic potential, some genotypes are more frequently implicated in the occurrence of cancer cases than others. Most commonly, genotypes such as HPV 16 and HPV 18 account for approximately 70% of all cervical cancers worldwide, and HPV 31, HPV 33, HPV 45, HPV 52, HPV 58 and HPV 68 are among the remaining ten HR-HPV genotypes that are often isolated from cervical tumour biopsies.
PROJECT 7 : Climate change, food security and the new frontiers of traditional medicine in the
context of responsible research and innovation and the one health concept. PhD Student: Abel
DAFOGO DJIBAGAOU. Financial support: Tor Vergata & CNR (Italian Cooperation)
Description : The Responsible Research and Innovation (RRI) approach and the One Health concept are essential to meeting the challenges of the Sahel, a region facing interconnected human, animal and environmental health problems. Climate change directly affects food security by reducing agricultural yields, degrading natural resources and disrupting food markets, threatening food access and availability. Vulnerable populations, such as small-scale farmers, rural communities and women, are particularly at risk. To mitigate these impacts, solutions such as resilient agriculture, sustainable resource management and supportive international policies are needed. Initiatives such as the Great Green Wall and climate-smart agriculture are examples of success. Traditional Medicine refers to health practices, methods, knowledge and beliefs that involve the use for medical purposes of plants, animal parts and minerals, spiritual therapies, techniques and manual exercises separately or in combination to treat, diagnose and prevent disease or maintain health.
Nutraceutique is a term born from the contraction of ‘’nutrition‘’ with ‘’pharmaceutical‘’. Its synonym is a combination of two relative words: ‘’aliment‘’ and ‘’médicament‘’. Traditional medicine and nutraceuticals exploit the properties of natural products to promote health. Traditional medicine is based on ancestral knowledge and a holistic approach, while nutraceuticals modernise these practices by isolating and standardising active ingredients for targeted prevention.